What are the reproductive issues?
Once you know you have the p53 gene mutation, you may wonder what the possibility of having a child with Li-Fraumeni Syndrome is. Individuals with LFS have a 50% chance of passing the gene mutation to their children. If a defective p53 gene mutation is passed on, it can cause LFS. This is termed autosomal dominance. Often a diagnosis of LFS is given before or during childbearing years. For people with LFS, the decision to have children can be difficult and intensely personal, due to the possibility of passing the p53 gene mutation on to child or developing cancer as a parent. Some people with LFS have used options such as sperm/egg donors, or pre-implantation genetic diagnosis to ensure their children do not inherit this mutation. There are many qualified experts such as oncologists, genetic counselors and fertility specialists that can help provide valuable information if needed when making this decision.