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What causes LFS?

LFS AssociationLi Fraumeni Syndrome is caused by a gene mutation in the p53 tumor suppressor gene. Most people with LFS have a genetic mutation that is passed on from a parent. Occasionally, LFS can result from a new gene mutation (de novo) without having parents affected or a family history of cancer. Not all families with LFS have a p53 gene mutation. There are many types of p53 gene mutations, which can behave differently in every person and within each family. Some families with LFS have very high rates of cancer incidence, while others don’t. The degree to which a p53 gene mutation causes cancer in a family or person is termed “penetrance.”

The p53 gene can function a little bit or not at all depending on the type of mutation to the area of the gene. Every cell has 2 copies of a gene, one from the person’s mother and one from the father. The mutated form of p53 is dominant, which means if you have a normal copy of the gene and a mutated form of the gene, you will see the effects of the mutated gene, in this case—a higher risk of developing cancer. If you have 2 normal genes, you will not see the effects. If someone with the gene mutation has children, then they have a 50% chance of passing along the gene mutation to their children. If you do not have the gene mutation, you will not pass along the effects to your children.

Cancers associated with LFS include adrenocortical cancer, brain tumors, soft tissue sarcomas, osteosarcomas, rhabdomyosarcoma, breast cancer, leukemia, lymphoma and glioblastoma. There are numerous other cancers that have been seen in LFS families, often occurring at younger ages than expected. Patients with LFS should seek input from healthcare providers experienced in caring for patients with Li-Fraumeni Syndrome.

LFS Association

We are families, like you who have been devastated by the effects of Li-Fraumeni Syndrome, a hereditary cancer predisposition syndrome. Our hopes are to educate, raise awareness and find better screening programs and treatments for LFS.


Medical Resources

We've compiled a list of doctors available to
answer your questions, LFS support and
treatment. They specialize in many different
areas, which have been listed with their


LFS News

WETB’s Gayle Ong was one of several reporters covering the event and story of LFS and Mo Songs for Kerry.

Read More…

Community Events

Carly Grant – Mohawk Hudson River Marathon 2017
Support Carly and the Li-Fraumeni Syndrome Association as she raises money and trains for the Mohawk Hudson River Marathon on October 8th!


LFS Webinars

Check out our library to watch past LFS
webinars, and to find out about
upcoming webinars!

Learn more...

LFS Awareness Brochure

Myriad Genetics is proud to partner with LFSA to launch the global LFS Education and Awareness Campaign!