LFS is caused by a variant in your TP53 tumor suppressor gene, which controls abnormal cell growth and prevents cancers from developing. Everyone has two copies of TP53 in each of their body’s cells. For those with LFS, one of the two TP53 genes do not function properly, or it may be missing altogether.
Most people with LFS inherited the variant from a parent, but LFS can also result de novo, without having affected parents or a family history of cancer. Each child of a parent with LFS has a 50% chance of inheriting the syndrome. For this reason, those who have had cancer at a young age or those with a family history of cancer should ask their doctor or a genetic counselor for a genetic test.
If you are pregnant or considering becoming pregnant, you should discuss the reproductive implications of LFS with your doctor or genetic counselor.
LFSA provides information, advocacy, and support services for individuals and families with Li-Fraumeni Syndrome and those who want to learn whether their family may be affected. LFSA supports a consortium of researchers, medical providers, and caregivers to advance research and promote optimal care for the LFS community.
LFSA is also a supportive community of Li-Fraumeni Syndrome families and survivors. We are the building blocks of a future without LFS. Together we bring together those who share this lifesaving goal.