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What is LFS?

LFS AssociationLi-Fraumeni Syndrome is a rare inherited genetic cancer disorder that greatly increases one’s risk of developing cancer during their lifetime. Sometimes people with LFS develop multiple cancers and multiple tumors often in childhood or as young adults. In 1969 Dr. Joseph Fraumeni noticed groups of families with a higher number of childhood cancers and adult early onset cancers. With the help of Dr. Frederick Li, they found increased numbers of genetic sarcomas, genetic leukemias, genetic adrenal cancer, and genetic breast cancer in these families than would normally be expected. This “familial cancer syndrome” ultimately became known as Li-Fraumeni Syndrome. In 1990 researchers found that LFS is most often caused by a gene mutation in the p53 tumor suppressor gene. When this p53 gene is mutated, it doesn’t work properly to stop cell growth and cancer tumors develop.

Cancers associated with LFS include adrenocortical cancer, brain tumors, soft tissue sarcomas, osteosarcomas, rhabdomyosarcoma, breast cancer, leukemia, lymphoma and glioblastoma. We now know that numerous other cancers have been seen in LFS families, often occurring at younger ages than expected. Due to the complexity of this disorder, it is recommended that patients with LFS seek input from providers experienced in caring for patients with this syndrome.

LFS Association

We are families, like you who have been devastated by the effects of Li-Fraumeni Syndrome, a hereditary cancer predisposition syndrome. Our hopes are to educate, raise awareness and find better screening programs and treatments for LFS.

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Medical Resources

We've compiled a list of doctors available to
answer your questions, LFS support and
treatment. They specialize in many different
areas, which have been listed with their
information.

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LFS News

Newly released articles from Drs. Frederick Li and Joseph Fraumeni.

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Community Events

Team Faces of LFS Color Run
Join or support Team Faces of LFS in The Color Run™ on June 11th, 2017!

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LFS Webinars

Check out our library to watch past LFS
webinars, and to find out about
upcoming webinars!

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LFS Awareness Brochure

Myriad Genetics is proud to partner with LFSA to launch the global LFS Education and Awareness Campaign!


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