OPENING REMARKS & KEYNOTE

• OPENING REMARKS – JUDY GARBER, MD, AND ROBERT LUFKIN, DO
• KEYNOTE – PROF. PIERRE HAINAUT, UNIVERSITY OF GRENOBLE, FRANCE

SESSION I: MODELING LFS

CHAIR: DR. DAVID MALKIN

• PROF. GARETH BOND, UNIVERSITY OF BIRMINGHAM, UK
• DR. ADAM SHLIEN, HOSPITAL FOR SICK CHILDREN, TORONTO, CANADA
• DR. JASON BERMAN, CHILDREN’S HOSPITAL OF EASTERN ONTARIO, OTTAWA,
• DR. EMILIA PINTO, ST. JUDE CHILDREN’S RESEARCH HOSPITAL, MEMPHIS, TN, USA
• PANEL Q & A: HAINAUT, BOND, SHLIEN, BERMAN, PINTO

SESSION II: PRECLINICAL THERAPEUTIC SCIENCE

CHAIR: PROF. ARNOLD LEVINE

• PROF. ARNOLD LEVINE, PRINCETON, NJ, USA
• DR. PAUL HWANG, NHLBI, NIH, BETHESDA, MD, USA
• DR. RAN KAFRI, TORONTO, CANADA
• PROF. VARDA ROTTER, WEIZMANN INSTITUTE, REHOVOT, ISRAEL
• PANEL Q & A: LEVINE, HWANG, KAFRI, ROTTER

SESSION III: CHALLENGES IN INTERPRETATION OF TP53 VARIANTS: LOW PENETRANCE ALLELES, ACE AND VUS

CHAIR: SHARON PLON

• DR. KARA MAXWELL, UPENN, PHILADEPHIA. PA, USA
• DR. SHARON SAVAGE, NCI, BETHESDA, MD, USA
• DR. THIERRY FREBOURG, ROUEN, FRANCE
• DR. JEFFREY WEITZEL, CITY OF HOPE, DUARTE, CA, USA
• PANEL Q & A: MAXWELL, WEITZEL, FREBOURG, SAVAGE

SESSION IV: PHENOTYPE: GENOTYPE CORRELATIONS

CHAIR: PHUONG MAI

• PROF. WENYI WANG, UTMDACC, HOUSTON, TX, USA
• PROF. DAVID THOMAS, GARVAN INSTITUTE, SYDNEY, AUSTRALIA
• PANEL Q & A: WANG, THOMAS

SESSION V: EARLY TUMOR DETECTION APPROACHES

CHAIR: SURYA REDNAM

• PROF. TREVOR PUGH, PRINCESS MARGARET CANCER CENTRE, TORONTO, CANADA
• DR. BRIAN CROMPTON, DFCI, BOSTON, MA, USA
• DR. ANNA GOLDENBERG, HOSPITAL FOR SICK CHILDREN, TORONTO, CANADA
• DR. STEPHEN FRIEND, SEATTLE, WA, USA
• PANEL Q & A: PUGH, CROMPTON, GOLDENBERG, FRIEND

SESSION VI: PSYCHOSOCIAL ISSUES AND COUNSELING IN LFS

CHAIR: KIM NICHOLS

• WENDY KOHLMANN, HUNTSMAN CANCER CENTER, SALT LAKE CITY, UTAH, USA
• DR. ANITA VILLANI, TORONTO, CANADA
• ROWAN FORBES-SHEPHERD, PETER MACCALLUM CANCER CENTRE, MELBOURNE, AUSTRALIA
• PANEL Q & A: VILLANI, FORBES-SHEPHERD, KOHLMANN

BREAST HEALTH & YOU

• Dr. Natália Polidorio, MD, Breast Surgeon at Hospital Sírio-Libanês, Brazil
• Dr. Maria Isabel Achatz, Hospital Sírio-Libanês, Brazil

OPENING REMARKS & KEYNOTE

• OPENING REMARKS: JENN PERRY, PRESIDENT LFSA
• KEYNOTE: DR. DAVID MALKIN, HOSPITAL FOR SICK CHILDREN, TORONTO, CANADA
1990-2020: Reflections on the Pearl Anniversary of LFS and p53

SESSION VII: SURVEILLANCE IN LI-FRAUMENI SYNDROME

CHAIR: LISA DILLER

• DR. MARY-LOUISE GREER, HOSPITAL FOR SICK CHILDREN, TORONTO, CANADA
Integrated imaging in LFS surveillance
• DR. MARIA ISABEL ACHATZ, HOSPITAL SIRIO-LIBANES, SAO PAOLO, BRAZIL
Updates from the Brazilian LFS registry: p.R337H TP53 and beyond
• DR. CHRISTIAN KRATZ, UNIVERSITY OF HANNOVER, HANNOVER, GERMANY
Brief report from the LFS registry in Germany: Diagnostic challenges, phenotype-genotype correlations, and surveillance
• DR. PATRICIA PROLLA, HOSPITAL DE CLINICAS PORTO ALEGRE, BRAZIL
Surveillance in carriers of the TP53 founder variant R337H
• PANEL Q & A: GREER, ACHATZ, KRATZ, PROLLA

SESSION VIII MISCELLANEOUS CLINICAL TOPICS IN LFS

CHAIR: HUMA RANA

• DR. JUNNE KAMIHARA, DFCI, BOSTON, MA, USA (Pediatric)
• DR. PHUONG MAI, U PITTSBURGH, PITTSBURGH, PA, USA (Adult)
• DR. MICHAEL WALSH, MSKCC, NEW YORK, NY, USA
Moving toward comprehensive care for individuals with Li-Fraumeni syndrome
• DR. BANU ARUN, MDACC, HOUSTON, TX, USA
Clinical characteristics of breast cancer patients with Li-Fraumeni syndrome
• PANEL Q & A: KAMIHARA, MAI, WALSH, ARUN

SESSION IX: COUNSELING ISSUES IN LFS

CHAIR: KATHERINE SCHNEIDER

• BITA NEHORAY, CITY OF HOPE, DUARTE, CA, USA
Beyond the basics: Genetic counseling issues in LFS
• SHARON BOBER, DFCI, BOSTON, MA, USA
Sexual health in the context of LFS
• YELENA WU, HUNTSMAN CANCER CENTER, SALT LAKE CITY, UTAH, USA
Supporting children and adolescents with Li-Fraumeni syndrome: Psychosocial considerations
• PANEL Q & A: WU, BOBER, NEHORAY

SESSION X: ARTIFICIAL INTELLIGENCE AND MACHINE LEARNING IN LFS

CHAIR: RAYMOND KIM

• DR. ANNA GOLDENBERG, HOSPITAL FOR SICK CHILDREN, TORONTO, CANADA
• DR. CATHERINE GOUDIE, MCGILL UNIVERSITY, MONTREAL, CANADA
Using eHealth to help clinicians identify cancer predisposition syndromes in children
• DR. JENNIFER MACK, DFCI, BOSTON, MA, USA
Using a chatbot to communicate about cancer risk and screening: The AYA-RISE intervention
• DR. STEPHEN FRIEND, SEATTLE, WA, USA
Nature vs Nurture: From genetic changes to how we live- exploring causal factors
• PANEL Q AND A: FRIEND, GOUDIE, MACK, GOLDENBERG

SESSION XI: LFS Studies

CHAIR: PAYAL KHINCHA

• LIFT-UP: DR. JUDY GARBER,DFCI, BOSTON, MA, USA / DR. JEFFREY WEITZEL, COH, DUARTE, CA, USA
• METFORMIN IN LFS: DR. PAYAL KHINCHA, NIH, BETHESDA, MD, USA / DR. SARAH BLAGDEN, OXFORD UNIVERSITY, OXFORD, UK / DR. DANIEL MORGENSTERN, HOSPITAL FOR SICK CHILDREN, TORONTO, CANADA (COMBINED)
• PANEL Q & A: GARBER, WEITZEL, KHINCHA, BLAGDEN, MORGENSTERN

SESSION XII: OPEN MIC PANEL

MODERATOR: DAVID MALKIN

JUDY GARBER, SHARON SAVAGE, CHRISTIAN KRATZ, GARETH EVANS, CLAIRE WAKEFIELD, ALISON SCHWARTZ, MEGAN FRONE

LFSA YOUTH & YOUNG ADULT PANEL

A unique opportunity for researchers and providers to ask questions of patients with LFS between the ages of 13-25. The youth team shared how they feel!

• LFSA YOUTH
• MODERATORS: KATHERINE SCHNEIDER, DANA-FARBER CANCER INSTITUTE & JENN PERRY, LFSA

WHAT RESILIENT PEOPLE KNOW & CLOSING REMARKS

• GINA VILD, CO-AUTHOR: HOW TO FIND YOUR PURPOSE – AND LIVE A HAPPIER, HEALTHIER LIFE
• MODERATOR: JENN PERRY, LFSA