Our friends at MD Anderson have published the results from their prospective study validating a new, user-friendly method in determining if genetic testing should be pursued, referred to as LFSPRO. Developed to assist genetic counselors, LFSPRO is a statistical tool that analyzes a patient’s full family history to estimate the likelihood of a TP53 mutation. By calculating these probabilities, the model more accurately identifies at-risk individuals than traditional criteria.
Wenyi Wang, Ph.D., Bioinformatics and Computational Biology: “Most risk prediction models are validated only in research-based cohorts, but our study demonstrates LFSPRO’s performance in a real-world genetic counseling setting, where limited family history information is provided within 30 minutes and most counselees test negative. Our model demonstrated substantially higher accuracy than current clinical guidelines and had strong concordance with genetic counselors’ judgment.”
Read the original publication: Performance of LFSPRO prediction in Tp53 mutation status for prospectively collected probands.
