2011: Monograph on Li-Fraumeni Syndrome by David Malkin
Li-Fraumeni syndrome (LFS) is a genetic disorder linked to mutations in the p53 tumor suppressor gene, leading to a wide range of
1988: A cancer family syndrome in twenty-four kindreds by Fred Li
Researchers analyzed families with a pattern of sarcomas, breast cancer, and other cancers occurring in young patients. They found that cancer developed
1987: Normal cytotoxic response of skin fibroblasts from patients with Li-Fraumeni familial cancer syndrome to DNA-damaging agents in vitro
Researchers tested cells from people with Li-Fraumeni Syndrome (LFS), a genetic condition that increases cancer risk, to see how they respond
Janaína
I lost my mother to cancer in 2018. She had two types: lung carcinoma and brain astrocytoma. They mentioned it
Fernanda
I discovered LFS in 2022 after treatment for advanced breast cancer! I needed to take the test because I
Reginalda
I discovered the syndrome through genetic testing after battling breast cancer and undergoing bilateral mastectomy. Today, I find myself navigating
Shirley
I discovered Li-Fraumeni syndrome one week before quadrant surgery for breast cancer. I found out about the cancer in April
Seeking Participants for the INFORM Research Study
Dana-Farber is leading an IRB-approved study that will screen for many of the deadliest cancers with a first-of-its-kind blood test. This test will
2011: Monograph on Li-Fraumeni Syndrome by David Malkin
Li-Fraumeni syndrome (LFS) is a genetic disorder linked to mutations in the p53 tumor suppressor gene, leading to
1988: A cancer family syndrome in twenty-four kindreds by Fred Li
Researchers analyzed families with a pattern of sarcomas, breast cancer, and other cancers occurring in young patients. They
1987: Normal cytotoxic response of skin fibroblasts from patients with Li-Fraumeni familial cancer syndrome to DNA-damaging agents in vitro
Researchers tested cells from people with Li-Fraumeni Syndrome (LFS), a genetic condition that increases cancer risk, to
Olivia
Olívia Naves, 22 years old, she never had cancer, from São Paulo, Brazil Hello! My name is Olívia Naves and I’m 22 years old. Having
Ana
Ana Caroline, 37 years old, from Belo Horizonte, Brazil. Never had cancer. When I was diagnosed with Li-Fraumeni, I was impacted in many ways because
Lakita
Lakita was born healthy with no medical issues in 2006 and loved dancing and art. At the age of 10 In the year (2017) she
Hot off the press!!! Genotype–phenotype associations within the Li-Fraumeni spectrum: a report from the German Registry.
In 2017, not only did Dr. Christian Kratz launch our international chapter, LFSA – Germany, but he also founded the German Cancer Predisposition Syndrome
New publication! Cancer surveillance for patients with LFS in Brazil
Dr. Maria Isabel Achatz led a recent publication on the cost-effectiveness of Cancer surveillance for patients with LFS in Brazil using the Toronto Protocol screening
NCI: Making Strides Toward Precision Medicine for Individuals with Li-Fraumeni Syndrome
Read about the advancements in LFS research that our team at the Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, have accomplished in their
