A milestone gathering brought together 46 members of the Li‑Fraumeni syndrome community in China to share knowledge, experiences, and hope. On October 25, 2026, the Li‑Fraumeni Syndrome Association (LFSA) China Chapter held its first family meeting in Shanghai, marking an important milestone in connecting individuals and families affected by Li‑Fraumeni syndrome (LFS) in China. The meeting welcomed
NEW: Radiation Exposure and Li-Fraumeni Syndrome Everyone is exposed to ionizing radiation, an invisible form of high-energy radiation, in everyday life. There are two main sources of radiation: naturally-occurring and man-made (usually medical). Naturally-occurring radiation can come from the ground and even outer-space! Examples of man-made radiation include x-rays, CT scans, and PET scans.
September is Ovarian Cancer Awareness Month! Although not originally recognized as a common “core” cancer in Li-Fraumeni syndrome (LFS), ovarian cancers were documented (1) as subsequent tumors in patients with Li-Fraumeni syndrome as early as 1988. And though still considered “rare” in LFS, reproductive cancers are highlighted in research. In an August 2026 study
Published August 2026, Li-Fraumeni Syndrome: Current Perspectives, is a comprehensive review on previously published work regarding molecular pathogenesis, international surveillance strategies, clinical management, and other pediatric considerations to include psychosocial implications, relative to LFS.
The Li-Fraumeni Syndrome Association (LFSA) is pleased to announce that applications are now open for the first annual Lesko-Fleming Empowerment Grant supporting adolescents and young adults with LFS. Through the tremendous generosity of the Lesko and Fleming families, this newly established annual grant program honoring the meaningful life and enduring memory of Cody Lesko
July 13, 2026 print edition The New York Times July 9, 2026 By Trip Gabriel Considered the founder of molecular epidemiology, he worked with Frederick P. Li to identify a hereditary disorder that increased the risk of developing cancer at a young age.Dr. Joseph F. Fraumeni Jr., who helped discover one of
Diagnosing Li-Fraumeni syndrome soon after a patient's first cancer can reduce their overall cancer burden with an improved, personalized plan. Faster identification enables earlier screening, proactive prevention, and better-informed treatment choices that minimize the risk of therapy-induced secondary cancers in women. Read more on the research published in Clinical Breast Cancer (June 2026) by our
Genetic testing is not always a one and done process: the classification of a variant may change over time, technologies improve and better testing may become available; and guidelines and recommendations for testing and management change as we learn new information. This case in “Genetic Testing Challenges in Oncology" highlights some of these issues. The
Through the tremendous generosity of the Lesko and Fleming families, a newly established annual grant program will provide support for two youth personally impacted by Li-Fraumeni syndrome. Honoring the meaningful life and enduring memory of Cody Lesko, the empowerment grants will support adolescents and young adults to offset costs of enriching wellness, mental health
Our friends at MD Anderson have published the results from their prospective study validating a new, user-friendly method in determining if genetic testing should be pursued, referred to as LFSPRO. Developed to assist genetic counselors, LFSPRO is a statistical tool that analyzes a patient's full family history to estimate the likelihood of a TP53 mutation.
P.O. Box 6458
Holliston, MA 01746, USA
Phone: 1-833-4MYLFSA (1-833-469-5372)
Email: info@lfsassociation.org
© Copyright 2026 | Li-Fraumeni Syndrome Association | All Rights Reserved | Terms & Conditions | Privacy Policy | Accessibility Statement
