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LFS News

Clinical Characteristics and Cancer Histories Among Breast Cancer Patients With Li-Fraumeni Syndrome From a Single Institution

Diagnosing Li-Fraumeni syndrome soon after a patient's first cancer can reduce their overall cancer burden with an improved, personalized plan.  Faster identification enables earlier screening, proactive prevention, and better-informed treatment choices that minimize the risk of therapy-induced secondary cancers in women.  Read more on the research published in Clinical Breast Cancer (June 2026) by our

By |2026-06-04T13:32:27-04:00June 4th, 2026|Genetic Testing, LFS News, Papers & Research Literature|0 Comments
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Key Points for Individuals with a Variant of Uncertain Significance (VUS) in the TP53 Gene

Genetic testing is not always a one and done process: the classification of a variant may change over time, technologies improve and better testing may become available; and guidelines and recommendations for testing and management change as we learn new information. This case in “Genetic Testing Challenges in Oncology" highlights some of these issues. The

By |2026-04-30T10:38:20-04:00April 29th, 2026|Genetic Testing, LFS News, Papers & Research Literature, Reference|0 Comments
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Lesko-Fleming Empowerment Grants

Through the tremendous generosity of the Lesko and Fleming families, a newly established annual grant program will provide support for two youth personally impacted by Li-Fraumeni syndrome. Honoring the meaningful life and enduring memory of Cody Lesko, the empowerment grants will support adolescents and young adults to offset costs of enriching wellness, mental health

By |2026-04-27T17:14:09-04:00April 27th, 2026|LFS News|0 Comments
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Novel tool more accurately predicts risk of Li-Fraumeni Syndrome

Our friends at MD Anderson have published the results from their prospective study validating a new, user-friendly method in determining if genetic testing should be pursued, referred to as LFSPRO.  Developed to assist genetic counselors, LFSPRO is a statistical tool that analyzes a patient's full family history to estimate the likelihood of a TP53 mutation.

By |2026-04-24T15:36:30-04:00April 23rd, 2026|Genetic Testing, LFS News, Papers & Research Literature|0 Comments
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Li-Fraumeni Syndrome Family Education Day at Children’s National

Families of children with Li-Fraumeni syndrome are invited to join a dedicated day of education, connection, and support at Children’s National Hospital. This Family Education Day will feature presentations from physicians, researchers, and care team members, along with updates on the latest research, clinical care, and future directions in LFS.Attendees will also have the opportunity

By |2026-03-31T11:16:35-04:00March 26th, 2026|LFS News|0 Comments
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Katherine M. Howley Endowment Fund for LFS Research

The Li-Fraumeni Syndrome Association (LFSA) is honored to announce the establishment of the Katherine M. Howley Endowment Fund for Li-Fraumeni Syndrome Research. This generous gift will allow the LFSA to award biennial research grants of up to $50,000 to the best and brightest minds in science who are working to discover and implement accessible

By |2026-03-16T10:45:53-04:00March 12th, 2026|LFS News|0 Comments
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Radiotherapy in Li-Fraumeni Syndrome: From Biological Concern to Personalized Clinical Decision-Making

The use of radiation is a challenge for Li-Fraumeni syndrome patients in regard to the increased risk of developing secondary, radiation-induced cancers.  However, advances in treatment protocols with radiation are rendering it a more viable option as deemed necessary in treating certain cancers.  This paper by researchers in Morocco reviews other papers on the topic

By |2026-01-13T14:38:05-05:00January 7th, 2026|LFS News, Papers & Research Literature|0 Comments
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Cancer’s Financial Impact on Young Adults – includes Financial Resources & Useful Tips

The American Association of Cancer Research (AACR) has published a useful article on the financial impact of young adults who have been diagnosed with cancer in their Cancer Today magazine.  The article provides financial resources (to include Dollar For, etc.) and practical tips for navigating the burden of medical costs (such as requesting payment plans with

By |2025-12-27T11:58:47-05:00December 27th, 2025|LFS News, Reference|0 Comments
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A prospective study of Annual Whole-Body MRI as Part of a Multimodality Screening Program for Individuals with Li-Fraumeni Syndrome

US-based researchers assessed the performance of (non-contrast) annual whole-body MRI as part of a multimodality screening for individuals with Li-Fraumeni syndrome for early cancer detection.  These researchers concluded that, in conjunction with other methods endorsed by LFS guidelines, annual wbMRI substantially contributes to the detection of localized, asymptomatic cancers across the spectrum of LFS.   The

By |2025-11-17T16:45:18-05:00November 14th, 2025|LFS News, Papers & Research Literature, Reference, Uncategorized|0 Comments
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Optimizing whole-body MRI for early cancer detection in Li-Fraumeni syndrome

New prospective data from a German study indicate that annual whole-body MRI for LFS surveillance could be shortened and may not require contrast agent while still detecting new cancers. Larger studies are needed before this becomes standard practice to ensure reliable detection across the entire, diverse LFS tumor spectrum. The goal is a patient-friendly,

By |2025-11-10T16:26:11-05:00October 29th, 2025|LFS News, Papers & Research Literature, Reference|0 Comments
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