Larry Ingrassia’s, A Fatal Inheritance, is the most comprehensive biography of Li-Fraumeni syndrome for the lay reader to date. Though this book reads like a riveting medical mystery, it is also an informative resource for
WHAT DOES IT MEAN TO BE A KICK-ASS FAIRY? Looking for a fairy tale to make into a musical? Look somewhere else. Linda Zercoe offers up a series of unfortunate events in a memoir that
Researchers tested cells from people with Li-Fraumeni Syndrome (LFS), a genetic condition that increases cancer risk, to see how they respond to DNA-damaging agents like X-rays. They found no significant differences between the cells of
Researchers analyzed families with a pattern of sarcomas, breast cancer, and other cancers occurring in young patients. They found that cancer developed in an autosomal dominant pattern, with 79% of affected individuals diagnosed before age
Li-Fraumeni syndrome (LFS) is a genetic disorder linked to mutations in the p53 tumor suppressor gene, leading to a wide range of cancers. While p53 mutations help explain some cancer risks, they don’t fully account
By Thierry Soussi
The history of p53 and the different interpretations of its role in cells highlight how scientific paradigms can shape research fields. It also provides valuable lessons for young scientists looking for an engaging
In October 2016, the American Association for Cancer Research organized a meeting with international experts on Li-Fraumeni Syndrome (LFS) to review the current understanding of
On November 2, 2010, the National Cancer Institute convened a workshop at the National
UK researchers conducted a retrospective case-series study of four children diagnosed with solid cancers at age 16 or younger, aiming to assess the time to and survival following a second cancer diagnosis.
Monograph on Li-Fraumeni syndrome written by Dr. David Malkin and edited by Arnold Levine: In 1969, Li and Fraumeni described a notable cancer predisposition syndrome. Using a classic epidemiological approach, they conducted
The two MHH researchers Lucas John Müntnich and Professor Christian Kratz refer to the cluster analysis of the study, according to which cancer-free survivalPublished by AACR in 2017, this publication was written by some of the invaluable members of LFSA’s Genetic Counseling Advisory Group. In this article, the authors present a genetic counseling framework
Published March 2025 by American Association for Cancer Research (AACR) is the updated version of the “Toronto Protocol,” the widely recognized screening recommendations for Li-Fraumeni syndrome patients, worldwide. Lead by Dr. David
The 2025 updated screening recommendations for individuals with Li-Fraumeni syndrome (LFS) are now available from the American Association for Cancer Research (AACR), as published in Clinical Cancer Research on May 15, 2025. These evidence-based updates
Cancer Resilient Elephants The tumor suppressor Tp53 is the most mutated gene in cancers. Germ-line variations in Tp53 lead to cancer predisposition, as noted in the Li-Fraumeni
Hosted by Upstate Medical University during Sarcoma Awareness Month, LFSA’s Kathy Higgins, Director of Education and Awareness, sat down with orthopedic oncologist and clinician-scientist Dr. Tim Damron regarding sarcomas and Li-Fraumeni syndrome (LFS).
New prospective data from a German study indicate that annual whole-body MRI for LFS surveillance could be shortened and may not require contrast agent while still detecting new cancers. Larger studies are
The use of radiation is a challenge for Li-Fraumeni syndrome patients in regard to the increased risk of developing secondary, radiation-induced cancers. However, advances in treatment protocols with radiation are rendering it a more viable
With advances in genetic testing, researchers and providers have been facing challenges in interpreting the pathogenic variants of TP53. Li-Fraumeni syndrome: not a straightforward diagnosis anymore—the interpretation of pathogenic variants of
Although the reduced risk of breast cancer with breastfeeding has not been studied with Li-Fraumeni syndrome, in particular, this review of breast feeding and the reduced risk of breast cancer is cause for further consideration.
Author Sharek A. Gadd was born in a midwestern commune 1971, and grew up in a nine-member family struggling with Li-Fraumeni syndrome. The illness, deaths, and grief drove Mr. Gadd to join the U.S. Army.
From Amazon: The story of the search for p53–the most important gene in medicine.
All of us have lurking in our DNA a most remarkable gene: it is known simply as p53
Proudly sponsored by the LFS Association and available through Amazon:
This book is a lighthearted introduction to Li-Fraumeni Syndrome (LFS), which is an inherited genetic predisposition to a wide range of cancers. In
LFS and Living My Best is an LFS resource for children aged 8 -13 by the LFS Association’s Genetic Counseling Advisory Group. Download and review the booklet and decide if it’s the
From Amazon: Mothers are superheroes when they’re battling cancer, and this empowering picture book gives them an honest yet spirited way to share the difficult experience with their kids.
Author Jessica ReidFrom Amazon: Butterfly Kisses and Wishes on Wings, an award-winning children’s book, is a powerful listen-to/read-aloud story for children with a family member or friend who has been diagnosed with cancer. The
Edited by our dear friend and late LFSA Medical and Scientific Advisory Board Member Pierre Hainaut, along with LFS researcher Klas Wiman, this 2005 compilation has helped launch the trajectory of TP53 and LFS research.
Still
From Amazon: The most comprehensive guide available on hereditary cancers, from understanding risk, prevention, and genetic counseling and testing to treatment, quality of life, and more.
Let There Be Light is a 2017 faith-based film about an atheist (Kevin Sorbo) who, after a serious car accident, “sees the light,” and is prompted to reevaluate his beliefs and life choices. In turn, he
PostCard 2LFS Association2024-02-14T17:34:17-05:00
