2011: Monograph on Li-Fraumeni Syndrome by David Malkin
Li-Fraumeni syndrome (LFS) is a genetic disorder linked to mutations in the p53 tumor suppressor gene, leading to a wide range of
1988: A cancer family syndrome in twenty-four kindreds by Fred Li
Researchers analyzed families with a pattern of sarcomas, breast cancer, and other cancers occurring in young patients. They found that cancer developed
1987: Normal cytotoxic response of skin fibroblasts from patients with Li-Fraumeni familial cancer syndrome to DNA-damaging agents in vitro
Researchers tested cells from people with Li-Fraumeni Syndrome (LFS), a genetic condition that increases cancer risk, to see how they respond
Fernanda
I discovered LFS in 2022 after treatment for advanced breast cancer! I needed to take the test because I
Reginalda
I discovered the syndrome through genetic testing after battling breast cancer and undergoing bilateral mastectomy. Today, I find myself navigating
Shirley
I discovered Li-Fraumeni syndrome one week before quadrant surgery for breast cancer. I found out about the cancer in April
Anna Carolina
I discovered that I have Li-Fraumeni syndrome in 2021. At the time, my mastologist asked me for a genetic
LFSA Co-Founder Debbie Soprano Honored by Boston Children’s Hospital
The Li-Fraumeni Syndrome Association (LFSA) is proud to announce that Co-Founder and Board Member Debbie Soprano has been recognized with the 2025 Employee
2011: Monograph on Li-Fraumeni Syndrome by David Malkin
Li-Fraumeni syndrome (LFS) is a genetic disorder linked to mutations in the p53 tumor suppressor gene, leading to
1988: A cancer family syndrome in twenty-four kindreds by Fred Li
Researchers analyzed families with a pattern of sarcomas, breast cancer, and other cancers occurring in young patients. They
1987: Normal cytotoxic response of skin fibroblasts from patients with Li-Fraumeni familial cancer syndrome to DNA-damaging agents in vitro
Researchers tested cells from people with Li-Fraumeni Syndrome (LFS), a genetic condition that increases cancer risk, to
Hot off the press!!! Genotype–phenotype associations within the Li-Fraumeni spectrum: a report from the German Registry.
In 2017, not only did Dr. Christian Kratz launch our international chapter, LFSA – Germany, but he also founded the German Cancer Predisposition Syndrome
New publication! Cancer surveillance for patients with LFS in Brazil
Dr. Maria Isabel Achatz led a recent publication on the cost-effectiveness of Cancer surveillance for patients with LFS in Brazil using the Toronto Protocol screening
NCI: Making Strides Toward Precision Medicine for Individuals with Li-Fraumeni Syndrome
Read about the advancements in LFS research that our team at the Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, have accomplished in their
Li-Fraumeni Syndrome Association Lauds Advancements in Classifying Hereditary Cancer Risks
HOLLISTON, MA -- The Li-Fraumeni Syndrome Association (LFSA), dedicated to furthering research and worldwide awareness of the inherited cancer predisposition disorder, celebrates new findings
Genetic Counselor Recommendations for Cancer Predisposition Evaluation and Surveillance in the Pediatric Oncology Patient
Published by AACR in 2017, this publication was written by some of the invaluable members of LFSA's Genetic Counseling Advisory Group. In this article,
Li-Fraumeni syndrome: report of a clinical research workshop and creation of a research consortium (and the LFS Association)
On November 2, 2010, the National Cancer Institute convened a workshop at the National Institutes of Health in Bethesda, Maryland, bringing together clinicians and scientists,
