Devoted to a world without inherited cancer

Monthly Archives: July 2025

p53 Prophylactic Therapy for Cancer Prevention

Cancer Resilient Elephants The tumor suppressor Tp53 is the most mutated gene in cancers.  Germ-line variations in Tp53 lead to cancer predisposition, as noted in the Li-Fraumeni syndrome (LFS) carriers. Currently, no options are available to delay or prevent cancer development in this population.  Conversely, animals such as elephants, are relatively resistant to

New 2025 AACR Screening Guidelines for Li‑Fraumeni Syndrome Now Available

The 2025 updated screening recommendations for individuals with Li-Fraumeni syndrome (LFS) are now available from the American Association for Cancer Research (AACR), as published in Clinical Cancer Research on May 15, 2025. These evidence-based updates offer important changes to surveillance protocols aimed at improving early cancer detection and care for individuals living with LFS. The

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