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Monthly Archives: January 2025

Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome (“Toronto Protocol”)

In October 2016, the American Association for Cancer Research organized a meeting with international experts on Li-Fraumeni Syndrome (LFS) to review the current understanding of the condition and propose consensus guidelines for surveillance. This summary provides an overview of the clinical and genetic aspects of this aggressive cancer predisposition syndrome. The expert panel concluded that

By |2025-07-01T15:08:20-04:00January 31st, 2025|Papers & Research Literature, Reference|0 Comments

Liquid Biopsy for Li-Fraumeni Syndrome Cancer Screening: Survey Study

We invite you to participate in a survey about your experiences receiving cancer screening for Li-Fraumeni Syndrome (LFS), and your thoughts about an upcoming clinical trial for people with LFS.Liquid biopsy is a promising new cancer screening technique that can detect signs of cancer in a blood sample, and researchers are planning a study adding

By |2025-01-13T11:07:07-05:00January 13th, 2025|LFS News|0 Comments

Neoantigenic properties of TP53 variants influence cancer risk in individuals with Li-Fraumeni syndrome

Immunotherapy has revolutionized the treatment of cancers in the last 15 years, demonstrating that a patient's very own immune system can seek and destroy a tumor even in its earlier stages. One of the most exciting findings from this research is the possibility that the immune system responds against non-inherited (spontaneous) mutations in the TP53

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