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Immunotherapy has revolutionized the treatment of cancers in the last 15 years, demonstrating that a patient's very own immune system can seek and destroy a tumor even in its earlier stages. One of the most exciting findings from this research is the possibility that the immune system responds against non-inherited (spontaneous) mutations in the TP53

US-based researchers assessed the performance of (non-contrast) annual whole-body MRI as part of a multimodality screening for individuals with Li-Fraumeni syndrome for early cancer detection.  These researchers concluded that, in conjunction with other methods endorsed by LFS guidelines, annual wbMRI substantially contributes to the detection of localized, asymptomatic cancers across the spectrum of LFS.   The